By Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD
Understand the entire crucial options in immunology with Basic Immunology: capabilities and issues of the Immune System! This concise, concentrated textual content offers you an up-to-date, obtainable advent to the workings of the human immune process.
- Efficiently grasp the immunology info you wish through clinically targeted content material, logically equipped by way of mechanism.
- Apply what you might have discovered to real-world events by referencing the appendix of scientific circumstances.
- Enhance your learning with assistance from a variety of full-color illustrations and precious tables, in addition to precis containers, overview questions, and a word list of immunology terms.
- Study immunology anywhere! on-line entry to www.StudentConsult.com opens the door to an greater ebook and ancillary components!
- Visualize advanced immunology suggestions with a totally up-to-date artwork program.
- Test your knowledge. New PowerPoint evaluation slides extra to www.StudentConsult.com are perfect for examine sessions.
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Additional resources for Basic Immunology: Functions and Disorders of the Immune System, 4e
IL-1 antagonists are effective treatments for these diseases. The common joint disease gout is caused by depoÂ�sition of urate crystals, and the subsequent inflammation is thought to be mediated by inflammasome recognition of the crystals and IL-1β production. The inflammasome may also contribute to atherosclerosis, in which inflammation caused by cholesterol crystals may play a role, and obesity-associated type 2 diabetes, in which IL-1 produced on recognition of lipids may contribute to insulin resistance of tissues.
TNF), which stimulate inflammation. Mast cell products also provide defense against helminths and are responsible for symptoms of allergic diseases (see Chapter 11). Natural Killer Cells Natural killer (NK) cells are a class of lymphocytes that recognize infected and stressed cells and respond by killing these cells and by secreting the macrophageactivating cytokine IFN-γ (Fig. 2–11). NK cells make up approximately 10% of the lymphocytes in the blood and peripheral lymphoid organs. NK cells contain abundant cytoplasmic granules and express some unique surface proteins, but do not express immunoglobulins or T cell receptors, the antigen receptors of B and T lymphocytes, respectively.
Naive T cells recognize these peptide-MHC complexes, and this is the first step in the initiation of T cell responses. Protein antigens also are recognized by B lymphocytes in the lymphoid follicles of the peripheral lymphoid organs. Polysaccharides and other nonprotein antigens are captured in the lymphoid organs and are recognized by B lymphocytes but not by T cells. As part of the innate immune response, the dendritic cells that present the antigen to naive T cells are activated to express molecules called costimulators and to secrete cytokines, both of which are needed, in addition to the antigen, to stimulate the proliferation and differentiation of T lymphocytes.
Basic Immunology: Functions and Disorders of the Immune System, 4e by Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD