By Eric Hollander
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Extra resources for Autism Spectrum Disorders (Medical Psychiatry Series)
Tanguay PE, Robertson J, Derrick A. A dimensional classiﬁcation of autism spectrum disorder by social communication domains. J Am Acad Child Adolesc Psychiatry 1998; 37:271–277. Stevens MC, Fein DA, Dunn M, Allen D, Waterhouse LH, Feinstein C, Rapin I. Subgroups of children with autism by cluster analysis: a longitudinal examination. J Am Acad Child Adolesc Psychiatry 2000; 39:346–352. Rapin I. Practitioner review—developmental language disorders: a clinical update. J Child Psychol Psychiatry 1996; 37:643–655.
To some extent, better deﬁnition of clinical symptoms through the development of valid and reliable diagnostic instruments, such as the Autism Diagnostic Interview–Revised (ADI-R) (11), has allowed for the collection of more homogeneous, or similar, study populations. Nevertheless, the above issues of heterogeneity, developmental variation, neurological comorbidity, and multiple-gene involvement contribute to difﬁculty in determining the neurobiology, brain mechanisms, and selective treatment response of autism.
Such cases include individuals with fragile X syndrome, tuberous sclerosis, neuroﬁbromatosis, hypomelanosis of Ito, marker chromosome, Moebius syndrome, or Rett’s syndrome (22). Most recently, success in the advancement of autism research has resulted from characterizing subjects based on core symptom domains. , Ref. 10). It is encouraging that results gained from this approach have been replicated (23). Replication with different subject samples lends more credibility to the ﬁndings. Family studies have demonstrated that these core symptom domains run in families (24,25).
Autism Spectrum Disorders (Medical Psychiatry Series) by Eric Hollander