By K. Pesek
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Additional info for Atherosclerotic Cardiovascular Disease
Even after menopause, cardiovascular risk is still significantly lower in women than in men of the same age. Nevertheless, in most developed countries cardiovascular diseases are the major causes of mortality in women, not only in men. 2 Menopause and hormonal therapy Women who enter menopause early (before age 50) are three times more likely to have coronary disease. Although some earlier studies suggested that there is an association between taking oral hormonal contraception (OHC) and the occurrence of coronary disease, today we know that (OHC) usage presents cardiovascular risk only in women with additional risk factors, especially smoking cigarettes.
And thus, disability of the heart ensues promptly. And when indeed a fainting spell is prolonged and movement and sensation in the body are lost, death occurs most frequently” (Stembrowicz, 1994). A lot is left to the imagination of the reader, as well as to the translation of the convoluted and highly scholastic text, abounding in philosophical adornments. In free translation and interpretation, the above quoted fragment might be easily regarded a description of a severe heart disease... In the 16th century Poland, the level of medical sciences - represented solely in Krakow - was relatively low.
As soon as only two years later, in 1881, he published his clinical observations of the use of the pharmaceutical. Based on experiments performed jointly with Michał Janocha, Korczyński introduced nitroglycerine to everyday clinical practice, on a large scale at that. He administered 1-6 drops of the drug and observed its effect on the circulatory system that lasted from 3 to 45 minutes, with the most pronounced effect occurring within 3-15 minutes. He described a simultaneous effect exerted on the nervous system and manifested - as reported by the patients - as a sense of warmth appearing inside the head and problems with attention focusing.
Atherosclerotic Cardiovascular Disease by K. Pesek