Frank Coke (Auth.)'s Asthma PDF

By Frank Coke (Auth.)

ISBN-10: 1483200396

ISBN-13: 9781483200392

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Contractions of the bronchus during Fig. —Horizontal section of Ellis's t u b e . ') normal respiration or under drugs can be read through the smaller tube. The main lumen of the larger tube allows air to pass through into the alveoli. Although there is regular contraction and expansion of the bag at each respiration, in Ellis's opinion this is entirely due to movement of the chest wall and not to the instrumentality of the bronchial muscle, for it occurs after the vagi have been severed. Ellis admits, however, that the bronchial muscle is in a state of tone, to be demonstrated by its relaxation with adrenaline, and in a tube whose calibre alters with each respiration it must be difficult to distinguish tone from muscular contraction when the calibre lessens.

Although I wrote the above three paragraphs fifteen years ago, there seems little to add or alter, except as to the paramount importance histamine is gaining in modern conceptions of asthma. One point of special interest is the disappearance of asthma in many women during pregnancy. All the three causes mentioned above, anaphylaxis, histamine, and Vaughan's split protein, have the power of causing contraction of the uterine muscle. Gross physiological contractions of this organ are obviously in abeyance during pregnancy, and the asthma disappears at the same time.

It is found beyond where the cartilage ceases to exist, and appears as irregular annular fasciculi, even in the smallest tubes. 3) Besides this annular arrangement, other muscular bands extend up and down in a manner called geodic in technical language, a word recently brought into prominence as a method of binding used to strengthen aeroplane struts. " The position of the muscle is shown in Fig. 1. It will be seen that the atria, infundibula, and final air-sac have no muscle present either to support or compress them.

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Asthma by Frank Coke (Auth.)

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