Download e-book for kindle: Apoptosis, Senescence and Cancer (Cancer Drug Discovery and by David A. Gewirtz, Shawn E. Holt, Steven Grant

By David A. Gewirtz, Shawn E. Holt, Steven Grant

ISBN-10: 1588295273

ISBN-13: 9781588295279

This publication offers perception into validated practices and examine into apoptosis and senescence. the amount completely examines novel and rising recommendations and learn within the fields of mobile dying pathways, senescence development arrest, medicinal drugs and resistance, DNA harm reaction, and different subject matters that also carry mysteries for researchers. In overall, this quantity offers simple scientists and clinicians with a deeper and extra entire knowing of the mobile responses of malignancies which can ascertain the effectiveness of therapy, either within the preliminary levels of the illness in addition to in sickness recurrence.

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Extra resources for Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development)

Sample text

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999; 10:105–15. 126. Epling-Burnette PK, Liu JH, Catlett-Falcone R, et al. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest 2001; 107(3):351–62. 127. Wang JM, Chao JR, Chen WS, Kuo ML, Yen JJ, Yang-Yen H-F. The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB.

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Live or let die: the cell’s response to p53. Nat Rev Cancer 2002; 2(8):594–604. 259. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61:759–67. 260. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 Mutations in Human Cancers. Science 1991; 253(5015):49–53. 261. Di Cristofano A, Pandolfi PP. The multiple roles of PTEN in tumor suppression. Cell 2000; 100: 387–90. 262. Hannun YA. Apoptosis and the dilemma of cancer chemotherapy. Blood 1997; 89(6):1845–53. 263.

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Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development) by David A. Gewirtz, Shawn E. Holt, Steven Grant


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