Download e-book for kindle: Antibody Fc. Linking Adaptive and Innate Immunity by Margaret Ackerman, Falk Nimmerjahn

By Margaret Ackerman, Falk Nimmerjahn

ISBN-10: 0123948029

ISBN-13: 9780123948021

Antibody Fc is the 1st unmarried textual content to synthesize the literature at the mechanisms underlying the dramatic variability of antibodies to persuade the immune reaction. The publication demonstrates the significance of the Fc area, together with protecting mechanisms, effector cellphone kinds, genetic facts, and variability in Fc area functionality. This quantity is a severe single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers in addition to graduate scholars in immunology and vaccinology.

Antibodies signify the correlate of safeguard for varied vaccines and are the main quickly turning out to be type of substances, with functions starting from melanoma and infectious sickness to autoimmunity. Researchers have lengthy understood the variable area of antibodies, that are liable for antigen acceptance, and will supply safeguard through blocking off the functionality in their objective antigen. in spite of the fact that, contemporary advancements in our realizing of the safety mediated by means of antibodies have highlighted the severe nature of the antibody consistent, or Fc area, within the organic job of antibodies. The Fc area permits antibodies to hyperlink the adaptive and innate immune platforms, delivering specificity to a variety of innate effector cells. additionally, they supply a suggestions loop to control the nature of the immune reaction through interactions with B cells and antigen-presenting cells.

  • Clarifies the various mechanisms of IgG task on the point of the various version platforms used, together with human genetic, mouse, and in vitro
  • Covers the function of antibodies in melanoma, infectious ailment, and autoimmunity and within the atmosphere of monoclonal antibody treatment in addition to obviously raised antibodies
  • Color illustrations improve factors of the immune system

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Extra info for Antibody Fc. Linking Adaptive and Innate Immunity

Sample text

Neurosci Lett 2009;464(1):29–33. Platt CD, Ma JK, Chalouni C, Ebersold M, BouReslan H, Carano RA, et al. Mature dendritic cells use endocytic receptors to capture and present antigens. Proc Nat Acad Sci USA 2010;107(9):4287–92. Flannagan RS, Harrison RE, Yip CM, Jaqaman K, Grinstein S. Dynamic macrophage “probing” is required for the efficient capture of phagocytic targets. J Cell Biol 2010;191(6):1205–18. Zhang Y, Hoppe AD, Swanson JA. Coordination of Fc receptor signaling regulates cellular commitment to phagocytosis.

Geier H, Celli J. Phagocytic receptors dictate phagosomal escape and intracellular proliferation of Francisella tularensis. Infect Immun 2011;79(6):2204–14. Yang X, Brunham RC. Gene knockout B cell-deficient mice demonstrate that B cells play an important role in the initiation of T cell responses to Chlamydia trachomatis (mouse pneumonitis) lung infection. J Immunol 1998;161(3):1439–46. Moore T, Ananaba GA, Bolier J, Bowers S, Belay T, Eko FO, et al. Fc receptor regulation of protective immunity against Chlamydia trachomatis.

26 ANTIBODY Fc 32 2. Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control Signaling by Activating FcγRs The clustering and cross-linking of FcγRs by immune complexes results in a coordinated signal transduction that initiates FcγR-mediated phagocytosis (reviewed in Garcia-Garcia and Rosales27 and Swanson and Hoppe28). 51,52 Because Rac is an important regulatory component of the NADPH oxidase complex, FcγR-mediated uptake results in oxidative burst and thus an inflammatory response, whereas complementmediated phagocytosis does not.

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Antibody Fc. Linking Adaptive and Innate Immunity by Margaret Ackerman, Falk Nimmerjahn


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