By Jamie V. Trapp, Tomas Kron
Combining features of health and wellbeing physics with drugs, An creation to Radiation safety in Medicine covers the historical past of the topic and the scientific occasions the place radiation is the device to diagnose or deal with human ailment. Encouraging novices to the sphere to correctly and successfully functionality in a flexible and evolving paintings atmosphere, it familiarizes them with the actual difficulties confronted throughout the program of ionizing radiation in drugs.
The textual content builds a primary wisdom base ahead of offering useful descriptions of radiation protection in drugs. It covers uncomplicated concerns relating to radiation safety, together with the actual technology in the back of radiation safety and the radiobiological foundation of radiation security. The textual content additionally offers operational and managerial instruments for organizing radiation protection in a clinical place of work. next chapters shape the center of the e-book, targeting the perform of radiation safety in numerous scientific disciplines. They discover a number of person makes use of of ionizing radiation in a variety of branches of drugs, together with radiology, nuclear drugs, exterior beam radiotherapy, and brachytherapy.
With contributions from skilled working towards physicists, this ebook presents crucial information regarding facing radiation security within the quickly transferring and numerous setting of medication
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In total body irradiation for therapeutic purposes immunosuppression is actually the desired effect. 26 The delay is due to the relatively slow turnover of blood cells. Without intervention (antibiotics, transfusions, bone marrow transplant) this hematopoietic syndrome (3–8 Gy) leads to death in 3–8 weeks. • Effects on the small intestine can be observed at doses between 5 and 20 Gy. Once the acute dose to the body exceeds 10 Gy, internal bleeding follows and death may occur within a few days due to GI tract depopulation of epithelium (gastrointestinal syndrome).
Genomic instability:18,19 Genomic instability describes a delayed mechanism of radiation damage and challenges the notion that radiation damage is manifest in the cells that are actually irradiated. It has been observed that genetic mutations and chromosomal damage can occur in many cell generations after the actual irradiation. While this effect appears to be not present in all cell lines and its mechanism is not clear, it would again have implications for the interpretation of radiation damage in the context of radiation protection.
Homologous recombination uses the second copy of DNA, which is available during the late S phase and G2 phase, to faithfully repair the damage using the intact copy. indb 46 2/1/08 11:38:13 AM Radiation and Risk: Radiobiological Background 47 Double strand breaks and other complex lesions are more difficult to repair. 10: • Homologous recombination (HR) makes use of the fact that in the S and G2 phases there are two copies of the DNA available. In this case, the undamaged copy can be used to facilitate a faithful repair.
An Introduction to Radiation Protection in Medicine by Jamie V. Trapp, Tomas Kron