By Ronald R. Watson
The 1st connection with gather the newest examine and reports at the therapy and pathogenesis of center illness in AIDS sufferers, this reference makes an attempt to enhance the prognosis, administration, and treatment of HIV-associated middle failure by means of learning the lengthy results of immunosuppression and opportunistic and viral an infection, in addition to cofactors affecting center ailment comparable to drug-related cardiotoxicity, cocaine abuse, and dietary deficiencies on cardiac functionality.
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Yokoo T, Kitamura M. Dual regulation of IL-1 beta-mediated matrix metalloproteinase-9 expression in mesangial cells by NF-kappa B and AP-1. Am J Physiol 1996; 270:F123– F130. 96. Arsura M, Wu M, Sonenshein GE. TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: transcriptional activation of I kappa B alpha. Immunity 1996; 5:31–40. 97. Krishnaswamy G, Kelley J, Johnson D, Youngberg G, Stone W, Huang SK, Bieber J, Chi DS. The human mast cell: functions in physiology and disease.
BFGF is a true angiogenic factor, which is also required for growth and maintenance of KS. The RGD sequence of tat is also able to induce the expression of a 72-kDa collagenase, a metalloproteinase that is important for mediating the invasive properties of KS. EFFECTS OF GP120 PROTEIN ON ENDOTHELIUM The envelope glycoprotein gp120 has several effects relevant to endothelial cell function, some of which could predispose the blood vessel to atherogenesis. Gp120 has been shown to alter endothelial permeability and to induce endothelial cell apoptosis.
22. Brand K, Page S, Walli AK, Neumeier D, Baeuerle PA. Role of nuclear factor-kappa B in atherogenesis. Exp Physiol 1997; 82:297–304. 23. Navab M, Fogelman AM, Berliner JA, Territo MC, Demer LL, Frank JS, Watson AD, Edwards PA, Lusis AJ. Pathogenesis of atherosclerosis. Am J Cardiol 1995; 76:18C– 23C. 24. Collins T. Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion. Lab Invest 1993; 68:499–508. 25. Brand K, Page S, Rogler G, Bartsch A, Brandl R, Knuechel R, Page M, Kaltschmidt C, Baeuerle PA, Neumeier D.
AIDS and Heart Disease by Ronald R. Watson